Can genetically normal embryos still miscarry?

Yes. A euploid result reduces the risk of miscarriage but does not remove it. ASRM (2026) notes that miscarriage still occurs in 10 to 20% of pregnancies after PGT-A. Why: The biopsy tests a few cells from the placental lineage, which may not represent the whole embryo. Mosaicism can mean the tested cells differ from the rest. The technology has limits — it cannot detect uniparental disomy, and it does not assess single genes or structural abnormalities. Miscarriage has many causes unrelated to chromosomes: uterine factors such as polyps, fibroids or adhesions; thyroid dysfunction; antiphospholipid syndrome; and a substantial proportion where no cause is found. A point ASRM makes that is directly relevant if you have had repeated losses: women with recurrent pregnancy loss have a higher likelihood of euploid miscarriage than women with isolated losses, and that likelihood increases with the number of losses. So if you have miscarried several times, your losses are less likely to be chromosomal — which is exactly why a euploid transfer may still not resolve the problem. If you have had a miscarriage after a euploid transfer, it is reasonable to ask for evaluation of non-chromosomal causes: assessment of the uterine cavity, thyroid function, and antiphospholipid antibodies. And it was not caused by anything you did. That bears saying, because it is the question most people are really asking.