Can PGT-M be combined with PGT-A?

Yes, they can be done together on the same biopsy, and this is common where a couple has both a known genetic condition and other reasons to consider chromosome testing. ESHRE recommends that where combined PGT-M and PGT-A are offered, the couple receives comprehensive counselling about the possible findings and what they mean for which embryos can be transferred — because combining the two produces more result categories than either alone, and the transfer policy becomes more complex. ESHRE also states that regardless of the centre's specific policy, if embryos that are both unaffected by the condition and free of chromosome abnormalities are available, they should be given priority for transfer. The practical consequence to be prepared for: combining tests reduces the number of transferable embryos, sometimes considerably. An embryo unaffected by your genetic condition may be excluded on chromosome grounds, and vice versa. Couples are often surprised by how few embryos remain. Questions worth asking before you start: What will you do with an embryo that is unaffected by our condition but reported as mosaic? What is your transfer ranking policy when the two results disagree? How many embryos would you expect us to have available, given our situation? Whether adding PGT-A is worthwhile is a separate question from PGT-M. PGT-M addresses a known, specific, serious risk. The case for adding PGT-A is weaker and depends on your circumstances — it has not been shown to increase live birth rates for most patients. Have that conversation before the cycle, not when results arrive.