Can PGT-M prevent inherited diseases?

It substantially reduces the chance of having a child affected by the specific condition tested for. It does not eliminate it, and it does not address anything else. Why not entirely eliminated: a residual risk of misdiagnosis always remains. ESHRE recommends that this residual risk is calculated for your specific test set-up and stated in your work-up report — so you should have a number, specific to your family, rather than a general reassurance. The reasons a result can be wrong include allele drop-out, where one copy of a gene fails to amplify in the test; recombination between the genetic markers used and the gene itself; and sample contamination. Because of that residual risk, ESHRE recommends prenatal diagnosis is offered to all women who become pregnant following PGT. Cord blood testing after birth is an alternative if you prefer to avoid an invasive test. What PGT-M does not cover: Other genetic conditions not tested for. New gene changes arising spontaneously that neither parent carries. Chromosome problems, unless PGT-A is added. Structural abnormalities. Anything acquired during pregnancy or birth. So the accurate framing is that PGT-M dramatically reduces the risk of one specific condition you already know about. For a family that has lived with a serious inherited disease, that is a profound difference. It is not the same as guaranteeing a healthy child, and any clinic implying otherwise is overselling.