Should we do IVF with PGT-SR?

This is a genuine decision rather than a clear recommendation, and you should be given both sides. ASRM (2026) states the efficiency of PGT-SR versus expectant management has not been established. Couples should be counselled on all options, including unassisted conception and donor gametes. Reasons couples choose PGT-SR: Fewer miscarriages along the way. For couples who have had several losses, this is often the deciding factor and it is a legitimate one. A shorter emotional path to a live birth, even if the overall chance is not higher. Where fertility treatment is needed anyway, adding PGT-SR is a small additional step. Reasons couples choose natural conception with prenatal diagnosis: Live birth rates as high as 70 to 71% without assisted reproduction. No IVF, with its cost, physical demands and uncertainty. A balanced translocation substantially reduces transferable embryos — an average of at least 4.5 blastocysts was needed for a good chance of one in one study, meaning multiple retrieval cycles may be required. With advancing age or reduced ovarian reserve, IVF may not yield a transferable embryo at all. Factors that shift the balance: your age and ovarian reserve, how many losses you have had, the specific chromosomes involved, cost and access, and how you feel about the possibility of another miscarriage versus the possibility of IVF not working. Ask for genetic counselling that presents natural conception as a real option. If it is framed only as what happens if IVF fails, ask for a second opinion.